Location History:
- Mississauga, CA (1998 - 2001)
- Hong Kong, CN (2003)
Company Filing History:
Years Active: 1998-2003
Title: The Innovations of Vrijmoed Chi
Introduction
Vrijmoed Chi is a notable inventor based in Hong Kong, China. He has made significant contributions to the field of DNA sequencing and analysis. With a total of four patents to his name, Chi's work has advanced the methodologies used in genetic research and diagnostics.
Latest Patents
Chi's latest patents include a "Method and apparatus for alignment of signals for use in DNA base-calling." This invention involves aligning data traces from four channels of an automated electrophoresis detection apparatus by identifying peaks in each trace. The process includes normalizing the data traces to achieve uniform peak heights and determining coefficients of shift and stretch for selected data points. These coefficients are optimized to minimize the overlap of peaks in the combined normalized data traces, ultimately producing an aligned data set for display or base-calling processes.
Another significant patent is the "Method and system for DNA sequence determination and mutation detection." This method begins with obtaining raw fragment patterns for nucleic acid polymers. The raw patterns are conditioned using baseline correction and noise reduction techniques to yield clean fragment patterns. Normalization coefficients are then determined to correlate the clean fragment pattern with a standard fragment pattern. This normalized pattern is crucial for accurate base-calling in genetic analysis.
Career Highlights
Chi is currently associated with Visible Genetics Inc., where he continues to innovate in the field of genetic sequencing. His work has been instrumental in enhancing the accuracy and efficiency of DNA analysis techniques.
Collaborations
Chi has collaborated with notable colleagues such as Rodney D. Gilchrist and Ronald J. Green. Their combined expertise has contributed to the advancement of technologies in genetic research.
Conclusion
Vrijmoed Chi's contributions to the field of DNA sequencing through his innovative patents have significantly impacted genetic research. His work continues to pave the way for advancements in the understanding of genetic information.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.