Venkatachalam Angamuthu

Title: Venkatachalam Angamuthu: Innovator in Optically Active Antrocin Preparation

Introduction

Venkatachalam Angamuthu is a notable inventor based in Hualien, Taiwan. He has made significant contributions to the field of chemistry, particularly in the synthesis of optically active compounds. His innovative approach has led to the development of a unique process for preparing optically active antrocin.

Latest Patents

Venkatachalam holds a patent for a process titled "Process for preparing optically active antrocin." This invention outlines a method for synthesizing optically active antrocin through a series of chemical reactions. Initially, alkyl aluminum/TMSCN is used to react with decalenone to introduce the correct configuration of trans-decalone. The resulting racemic nitrile-decalone is then resolved with chiral diol by ketalization, producing two chromatography separable diasteromers. After a straightforward column chromatography, optically pure compounds are obtained. A critical step in this synthesis is formylation for lactone formation, followed by oxidation and olefination, completing the total synthesis in 10 steps with a 7% overall yield from commercially available 6-methoxy-2-tetralone.

Career Highlights

Venkatachalam is currently associated with Deyew Biotech Corp., where he continues to advance his research and development efforts. His work has been instrumental in enhancing the understanding and application of optically active compounds in various fields.

Collaborations

He has collaborated with notable colleagues, including Dar-Fu Tai and Yew-Min Tzeng, contributing to the success of his projects and the advancement of their shared research goals.

Conclusion

Venkatachalam Angamuthu's innovative work in the preparation of optically active antrocin showcases his expertise and dedication to the field of chemistry. His contributions are paving the way for future advancements in the synthesis of complex compounds.