This inventor holds 2 USPTO granted patents. Top assignees: American Home Products Corporation, Wyeth. Active years: 2001-2004.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2001-2004
Title: Vedrana S. Susulic: Innovator in Transcriptional Regulation
Introduction
Vedrana S. Susulic is a prominent inventor based in Princeton Junction, NJ (US). She has made significant contributions to the field of molecular biology, particularly in the area of transcriptional regulation of the human β3-adrenergic receptor gene. With a total of 2 patents, her work has implications for understanding gene expression and potential therapeutic applications.
Latest Patents
Her latest patents focus on the regulatory elements responsible for tissue-specific transcriptional regulation of the human β-adrenergic receptor (β-AR). One patent identifies a region localized between -6.50 and -6.30 kb of the proximal promoter, which contains three sequences that act synergistically to achieve full transcriptional activity. Segment A includes an Sp1 binding site, while segment B serves as a binding site for a trans-acting factor present in cells that constitutively express β-AR. This trans-acting factor is notably expressed in neuroblastoma (SK-N-MC) and brown adipose tissue cells, but is minimally present in CV-1, HeLa, or white adipose tissue cells. Segment C is characterized as an S1 nuclease-sensitive site with CCTT repeats. Recombinant vectors controlled by this transcriptional regulation region, particularly those containing segments B and C, provide a substrate for high-throughput assays, such as reporter gene assays, to identify compounds that can enhance the expression of β-AR.
Career Highlights
Throughout her career, Vedrana has worked with notable companies such as Wyeth and American Home Products Corporation. Her experience in these organizations has contributed to her expertise in the field of molecular biology and patent development.
Collaborations
One of her notable collaborators is Emir Duzic, with whom she has worked on various projects related to her patents and research.
Conclusion
Vedrana S. Susulic is a distinguished inventor whose work in transcriptional regulation has advanced our understanding of gene expression. Her contributions continue to influence the field and hold promise for future innovations.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile