Company Filing History:
Years Active: 2022-2025
Title: Innovations of Valentin Sluch in Gene Editing
Introduction
Valentin Sluch is a prominent inventor based in Cambridge, MA, known for his significant contributions to the field of gene editing. With a total of five patents to his name, he has been at the forefront of developing innovative solutions in cellular engineering.
Latest Patents
One of his latest patents focuses on gene-edited natural killer cells. This invention relates to engineered cells, such as induced pluripotent stem cells (iPSC) or natural killer (NK) cells, which comprise a disrupted B2M gene and an inserted polynucleotide encoding various components, including SERPINB9 and a fusion of IL15 and IL15Rα. The engineered cells may also include a disrupted CIITA gene and an inserted polynucleotide encoding a chimeric antigen receptor (CAR), which can be either an anti-BCMA CAR or an anti-CD30 CAR. Furthermore, these cells may have disruptions in several other genes, including ADAM17, FAS, CISH, and REGNASE-1. The patent also describes methods for producing these engineered cells and their therapeutic applications.
Career Highlights
Valentin Sluch has made remarkable strides in his career, particularly through his work at Crispr Therapeutics AG. His innovative research has positioned him as a key figure in the advancement of gene editing technologies.
Collaborations
He has collaborated with notable coworkers, including Alireza Rezania and Jason Gary Sagert, contributing to a dynamic research environment that fosters innovation.
Conclusion
Valentin Sluch's work in gene editing exemplifies the potential of innovative technologies to transform medical treatments. His patents and collaborations continue to pave the way for advancements in cellular therapies.