Location History:
- Prague, CZ (1977 - 1988)
- Praha, CZ (1989 - 1995)
Company Filing History:
1 out of 8 
1 out of 2 
1 out of 16 Years Active: 1977-1995
Title: Vaclav Trcka: Innovator in Pharmaceutical Chemistry
Introduction
Vaclav Trcka is a notable inventor based in Praha, Czech Republic. He has made significant contributions to the field of pharmaceutical chemistry, holding a total of 4 patents. His work primarily focuses on the development of novel compounds with potential therapeutic applications.
Latest Patents
Among his latest patents are the N-arylalkylderivatives of 2-aminomethyl-2,3-dihydro-1,4-benzodioxine and 2-Isopropyl-2-(2-methylphenyl)-5-(N-methyl-N-homoveratrylamino)-valeronitrile, commonly known as 'mepamil'. The claimed compound is preferably administered in the form of water-soluble acid addition salts, such as hydrochloride. The preparation of this compound involves the alkylation of 2-(2-methylphenyl)-3-methylbutyronitrile with 3,3-diethoxypropylchloride. The resulting product undergoes mild acidic hydrolysis to yield the appropriate aldehyde, which is then reacted with N-methylhomoveratrylamine under conditions of reductive alkylation.
Career Highlights
Vaclav Trcka has worked with prominent companies in the pharmaceutical industry, including Spofa United Pharmaceutical Works and Spofa Spojene Podniky Pro Zdravotnickou. His experience in these organizations has contributed to his expertise in drug development and innovation.
Collaborations
Throughout his career, Vaclav has collaborated with notable colleagues, including Miroslav Rajsner and Ivan Helfert. These partnerships have fostered a collaborative environment that has enhanced his research and development efforts.
Conclusion
Vaclav Trcka's contributions to pharmaceutical chemistry and his innovative patents highlight his role as a significant inventor in the field. His work continues to influence the development of new therapeutic compounds.