Company Filing History:
Years Active: 2018-2023
Title: Innovations of Tyler A. Garretson
Introduction
Tyler A. Garretson is an accomplished inventor based in Oxford, Ohio. He has made significant contributions to the field of biotechnology, particularly in the development of plasmid vectors and recombinant baculovirus expression systems. With a total of two patents to his name, Garretson's work has the potential to impact various applications in genetic engineering and protein expression.
Latest Patents
Garretson's latest patents include innovations related to donor plasmid vectors. These vectors, such as pFastBac™1 and pFastBac™ Dual, have been engineered to lack a cis DNA element upstream of the polh translation start codon (ATG) found in wild type multiple nucleopolyhedrovirus (AcMNPV). By inserting a cis DNA element upstream of the 50 bp polh promoter and replacing the SV40 pA with an AcMNPV polh pA signal, certain protein expression levels in High Five™ cells using the Bac-to-Bac® system have reached those of the wild type AcMNPV. Additionally, he has developed a recombinant baculovirus expression vector that includes an engineered baculovirus fp25k gene with modified or mutated spots, which comprise two 7-adenine mononucleotide repeats (MNR) and the 10TTAA site. This invention also outlines the method for creating the vector and baculovirus.
Career Highlights
Garretson is affiliated with Miami University, where he continues to advance his research and innovation in biotechnology. His work has garnered attention for its potential applications in various scientific fields, including pharmaceuticals and agricultural biotechnology.
Collaborations
Throughout his career, Garretson has collaborated with notable colleagues, including Xiao-Wen Cheng and Hui Shang. These partnerships have contributed to the development of his innovative technologies and have fostered a collaborative research environment.
Conclusion
Tyler A. Garretson's contributions to biotechnology through his patents and research at Miami University highlight his role as a significant inventor in the field. His work on donor plasmid vectors and recombinant baculovirus expression systems showcases the potential for advancements in genetic engineering and protein production.
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