Tsuneo Unuma

Title: Tsuneo Unuma: Innovator in Tissue Plasminogen Activator Production

Introduction

Tsuneo Unuma is a notable inventor based in Ootsu, Japan. He is recognized for his contributions to the field of biotechnology, particularly in the production of tissue plasminogen activator (tPA). His innovative approach has implications for medical treatments, especially in the area of thrombolysis.

Latest Patents

Unuma holds a patent for a process for producing tissue plasminogen activator. This invention discloses a method that involves cultivating Escherichia coli, yeast, or mammalian cells that have been genetically modified to include the gene for human tPA through recombinant DNA technology. The process includes the addition of a specific antiplasmin agent during cultivation or purification to prevent the conversion of single-chain tPA into double-chain tPA by proteases present in the medium. This patent highlights Unuma's significant contribution to medical biotechnology.

Career Highlights

Throughout his career, Tsuneo Unuma has worked with prominent companies such as Toyo Boseki Kabushiki Kaisha and Daiichi Seiyaku Co., Ltd. His experience in these organizations has allowed him to develop and refine his innovative processes in biotechnology.

Collaborations

Unuma has collaborated with notable colleagues, including Ryotaro Kotani and Shigeki Otawara. These partnerships have contributed to the advancement of his research and the successful development of his patented processes.

Conclusion

Tsuneo Unuma's work in the production of tissue plasminogen activator showcases his innovative spirit and dedication to advancing medical biotechnology. His contributions have the potential to impact therapeutic practices significantly.