Location History:
- Osaka, JP (1992 - 1997)
- Toyonaka, JP (1988 - 2003)
Company Filing History:
3 out of 1,430 
2 out of 6,896 Years Active: 1988-2003
Title: The Innovative Mind of Toshiyuki Sakaki
Introduction
Toshiyuki Sakaki is a prominent inventor based in Osaka, Japan, known for his significant contributions to the field of chemical safety evaluation. With a total of four patents to his name, Sakaki has made strides in researching methods to assess the safety of chemical compounds, particularly utilizing recombinant yeast technologies.
Latest Patents
Among Sakaki's latest patents is a groundbreaking method for the safety evaluation of chemical compounds using recombinant yeast expressing human cytochrome P450. This method includes the steps of reacting a chemical compound with recombinant yeast cells that produce various human cytochrome P450 molecular species. The process allows for the analysis of the resulting metabolites to determine whether the chemical can be converted into carcinogenic or mutagenic forms in the human liver.
Another notable patent by Sakaki focuses on mitochondrial P450 expression in yeast. This invention includes a chimeric P450 with modifications to yeast mitochondrial protein signals and outlines a comprehensive process for producing specific enzymes and compounds, including 5β-cholestane-3α, 7α, 12α, 27-tetrol and 1α,25-dihydroxyvitamin D3.
Career Highlights
Throughout his career, Toshiyuki Sakaki has held esteemed positions, including serving as the Director-General of the Agency of Industrial Science and Technology, as well as working with Sumitomo Chemical Company, Limited. His leadership roles demonstrate his commitment to advancing industrial science and safety evaluation technologies.
Collaborations
Sakaki has collaborated with notable colleagues in his field, including Yoshiyasu Yabusaki and Hideo Ohkawa. These collaborations have likely fueled innovative ideas and expanded the reach of his research, contributing to the advancements in safety evaluations of chemical compounds.
Conclusion
Toshiyuki Sakaki's innovative work in the field of chemical safety evaluation through his patents showcases his dedication to improving public health and safety. His contributions to the development of advanced methodologies for assessing chemical compounds signify a pivotal advancement in the field, marking him as a distinguished inventor in contemporary science.