Toohyon Cho

Title: Innovations by Inventor Toohyon Cho

Introduction

Toohyon Cho, a notable inventor based in Philadelphia, PA, has contributed significantly to the field of biotechnology. With a total of six patents to his name, Cho has focused his research on improving the production and purification of adenoviral vectors, which are crucial in various therapeutic applications, including gene therapy.

Latest Patents

Cho's latest patents revolve around enhancing the efficiency of adenoviral vector production. His invention titled "Method for the Production and Purification of Adenoviral Vectors" addresses the challenges of yield improvement in cell culture systems. It highlights the advantages of using low-medium perfusion rates in attached cell culture systems. Additionally, the invention demonstrates improved Ad-p53 production from serum-free suspension cultures. The incorporation of detergent lysis further enhances yields, allowing for the purification of the virus through a single chromatography step, achieving quality comparable to traditional methods involving ultracentrifugation.

Career Highlights

Throughout his career, Cho has worked with notable organizations, including Introgen Therapeutics Inc. and Crucell Holland B.V. These experiences have enriched his expertise and contributed to his innovative technical solutions in the biotechnology sector.

Collaborations

Cho has collaborated closely with fellow researchers, including Shuyuan Zhang and Capucine Thwin. These partnerships reflect the collaborative nature of scientific research, fostering a creative environment that leads to significant advancements in the field.

Conclusion

Toohyon Cho's innovations in adenoviral vector production and purification mark vital progress in biotechnology. His contributions are invaluable in the ongoing quest to develop effective therapies. As research in this domain continues to evolve, Cho's patented methods will likely play an essential role in driving future innovations.