This inventor holds 1 USPTO granted patent. Top assignee: Cornell University. Active years: 1993.
Company Filing History:
Years Active: 1993
Title: Todd W Gusek: Innovator in Protease Development
Introduction
Todd W Gusek is a notable inventor based in Ithaca, NY (US). He has made significant contributions to the field of biochemistry, particularly in the development of proteases. His work has implications for various industries, including food processing and biotechnology.
Latest Patents
Todd W Gusek holds a patent for an "Alkali and heat stable protease from Thermomonospora fusca." This exocellular protease exhibits several unique physicochemical properties. The molecular mass of the protease ranges from about 10,000 to 14,000 Daltons, as determined by SDS-polyacrylamide gel electrophoresis. The protease activity is inhibited by serine protease inhibitors, indicating its specificity. It is a non-specific protease capable of hydrolyzing food proteins and bovine serum albumin at a rate of 50-100 nmoles peptide bonds per microgram of enzyme per minute at 55 degrees Celsius and pH 8.5 in 0.5 M Tris buffer. The protease demonstrates a broad spectrum of activity, being at least five times more effective than trypsin or chymotrypsin towards food-grade proteins. Its optimum activity temperature is 80 degrees Celsius at a pH of 8.0, with a temperature range of 35 to 95 degrees Celsius. The pH activity range is from about 7 to 11, with an optimum pH value of 9.0. The protease is tolerant to ionic strengths from 0.0 to about 1.0 M NaCl, with an optimum ionic strength of 0.2 M NaCl. Its isoelectric point is at an alkaline pH, and structurally, the protease is a monomer.
Career Highlights
Todd W Gusek is affiliated with Cornell University, where he continues to advance research in protease applications. His innovative work has garnered attention in the scientific community, contributing to advancements in enzymatic processes.
Collaborations
He has collaborated with notable colleagues, including David B Wilson and John E Kinsella, enhancing the scope and impact of his research.
Conclusion
Todd W Gusek's contributions to the field of protease development exemplify the importance of innovation in