Todd Hansen

Title: Innovations by Todd Hansen in Ion Channel Research

Introduction

Todd Hansen is an accomplished inventor based in Norfolk, VA (US). He has made significant contributions to the field of biomedical research, particularly in the area of ion channels and their implications in various diseases. His innovative work focuses on developing molecules that can effectively block specific ion channels, which are crucial in the treatment of conditions such as pain, epilepsy, and prostate cancer.

Latest Patents

Todd Hansen holds a patent related to "Na channels, disease, and related assays and compositions." This patent discloses molecules and their synthesis for use in blocking gated ion channels, specifically voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). The inhibitors he developed demonstrate superior blocking efficacy, particularly in displacing the radioligand [H]-Batrachotoxin-B ([H]-BTX-B) that binds to site 2 of a VGSC. The molecules include a moiety that enhances the binding affinity for the protein binding site in prostate cancer cells (PCs) and is also fluorescent. This invention provides an inhibition system that selectively targets over-abundant or hyperactive VGSCs, thereby inhibiting the proliferation of PCs. The fluorescent moiety facilitates screening, tracking, and pharmacodynamic studies of the drug in biological systems both in vitro and in vivo.

Career Highlights

Todd Hansen's career is marked by his dedication to advancing medical research through innovative solutions. His work at Georgetown University has positioned him as a key figure in the exploration of ion channel inhibitors. His research not only contributes to scientific knowledge but also has the potential to lead to new therapeutic strategies for serious health conditions.

Collaborations

Todd has collaborated with notable colleagues, including Milton L. Brown and Scott Grindrod. These partnerships have enriched his research endeavors and fostered a collaborative environment that encourages innovation.

Conclusion

Todd Hansen's contributions to the field of ion channel research exemplify the impact of innovative thinking in medicine. His patented work on VGSCs and PVSCs holds promise for developing targeted therapies for various diseases. His ongoing research at Georgetown University continues to pave the way for advancements in biomedical science.