Company Filing History:
Years Active: 2014
Title: Todd D Prickett: Innovator in Melanoma Research
Introduction
Todd D Prickett is a notable inventor based in Sterling, VA (US). He has made significant contributions to the field of melanoma research, holding 2 patents that focus on the genetic mutations associated with this aggressive form of skin cancer. His work has implications for both diagnosis and treatment, showcasing the intersection of genetics and oncology.
Latest Patents
Prickett's latest patents include groundbreaking research on GRM3 mutations and their use in diagnosing and treating melanoma. This patent describes a G-protein coupled receptor (GPCR)-directed mutational analysis of tumor DNA obtained from melanoma tissue samples. The GPCR gene glutamate receptor, metabotropic 3 (GRM3), was identified as the most highly mutated GPCR gene in this analysis. Functional characterization of GRM3 mutants revealed that these mutations promote activation of MEK, anchorage-independent cell growth, and metastasis. The patent outlines methods for diagnosing melanoma by detecting GRM3 mutations and suggests therapeutic approaches involving GRM3 inhibitors.
Another significant patent focuses on the use of ERBB4 as a prognostic and therapeutic marker for melanoma. This research discloses novel somatic mutations in the ERBB4 gene that lead to increased kinase activity and tumorogenicity. The patent provides methods for predicting patient prognosis based on ERBB4 mutations and identifies potential treatment candidates for inhibitors targeting the ERBB4 and PI3K/AKT pathways.
Career Highlights
Todd D Prickett is affiliated with the National Institutes of Health, a component of the US Department of Health & Human Services. His work at this prestigious institution has allowed him to contribute to vital research in cancer genetics and treatment strategies.
Collaborations
Prickett has collaborated with notable colleagues, including Yardena R Samuels. These collaborations have further enriched his research and expanded the impact of his findings in the field of melanoma.
Conclusion
Todd D Prickett's innovative work in melanoma research exemplifies the importance of genetic analysis in developing effective diagnostic and therapeutic strategies. His contributions continue to advance the understanding of melanoma and improve patient outcomes.