Location History:
- Bridgeport, PA (US) (2001)
- Yardley, PA (US) (2003 - 2014)
Company Filing History:
Years Active: 2001-2014
Title: The Innovations of Timothy M Malloy
Introduction
Timothy M Malloy is a notable inventor based in Yardley, PA (US). He has made significant contributions to the field of pharmaceuticals, particularly in the formulation of epothilone analogs. With a total of 9 patents to his name, Malloy's work has had a considerable impact on drug delivery systems.
Latest Patents
One of his latest patents is titled "Parenteral formulation for epothilone analogs." This invention discloses a process for formulating certain epothilone analogs for parenteral administration. The analog is dissolved in a mixture of at least 50% by volume tertiary-butanol in water, which is then lyophilized. The resulting lyophilized product is packaged in one vial with a sufficient amount of solvent comprising anhydrous ethanol and a suitable nonionic surfactant in a second vial. All steps are carried out with protection from light. In use, the contents of the second or diluent vial are added to the lyophilized product and mixed to constitute the epothilone analog. The resulting solution is diluted with a suitable diluent to produce a solution for intravenous injection containing the epothilone analog in a concentration of from about 0.1 mg/mL to about 0.9 mg/mL. A preferred surfactant is polyethoxylated castor oil, and a preferred diluent is Lactated Ringer's Injection. Another significant patent relates to "Pharmaceutical compositions, dosage forms and methods for oral administration of epothilones." This invention focuses on methods of increasing the bioavailability of orally administered epothilones, ensuring they are sufficiently bioavailable to have a pharmacological effect.
Career Highlights
Timothy M Malloy is currently associated with Bristol-Myers Squibb Company, where he continues to innovate in the pharmaceutical sector. His work has been instrumental in advancing the understanding and application of epothilones in medical treatments.
Collaborations
Throughout his career, Malloy has collaborated with esteemed colleagues such as Krishnaswamy Srinivas Raghavan and Sailesh A Varia. These collaborations have further enriched his research and development efforts.
Conclusion
Timothy M Malloy's contributions to the field of pharmaceuticals
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