Location History:
- Seattle, WA (US) (1998)
- Pasadena, CA (US) (1992 - 2001)
Company Filing History:
Years Active: 1992-2001
Title: The Innovative Mind of Tim J. Hunkapiller
Introduction
Tim J. Hunkapiller is an esteemed inventor based in Pasadena, California, recognized for his significant contributions to the field of DNA sequencing technology. With a portfolio of three patents, Hunkapiller continues to innovate at the forefront of genetic research.
Latest Patents
Hunkapiller's latest patents showcase his groundbreaking work in DNA analysis. His invention of tagged extendable primers and extension products provides a novel duplex that chemically couples oligonucleotide primers to chromophores or fluorophores, facilitating chain extension by a polymerase. This advancement allows the primer to be effectively extended, generating the complement of a template. Notably, the method includes the separation of the extended primer for use in various applications, including sequencing reactions.
Additionally, he developed an automated DNA sequencing technique that utilizes chromophores or fluorophores to tag DNA fragments produced during sequencing operations. This process enables the detection and characterization of these fragments as they undergo electrophoresis through a gel. The system features a source for tagged DNA fragments, a zone for electrophoresis, means for introducing the fragments, and photometric tools to monitor their movement through the gel.
Career Highlights
Hunkapiller's career at the California Institute of Technology has been marked by his unwavering commitment to advancing molecular biology. His work is instrumental in pushing the boundaries of genetic sequencing, making significant strides towards the accuracy and efficiency of DNA analysis.
Collaborations
Throughout his career, Hunkapiller has collaborated with prominent figures in the scientific community, including Lloyd M. Smith and Leroy E. Hood. These partnerships underline the importance of collaborative efforts in science, as they bring together diverse expertise to tackle complex problems in genetics.
Conclusion
Tim J. Hunkapiller's contributions to the field of biotechnology reflect his innovative spirit and dedication to scientific progress. As he continues to develop advanced technologies for DNA sequencing, he remains a key figure in the landscape of modern genetic research.