Company Filing History:
Years Active: 2014
Title: Innovations by Thomas R Ioerger
Introduction
Thomas R Ioerger is a notable inventor based in College Station, TX (US). He has made significant contributions to the field of biotechnology, particularly in the fight against tuberculosis. His work focuses on developing compounds that inhibit the activity of Mycobacterial malate synthase, an enzyme crucial for the survival of the bacteria that cause tuberculosis.
Latest Patents
Ioerger holds a patent titled "Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof." This invention provides aryl- or heteroaryl-diketo acid compounds that effectively inhibit the activity of Mycobacterial malate synthase. The compounds may include phenyl-, naphthyl-, or thienyl-substituted diketo acids and their carboxylate derivatives. The patent also outlines methods for treating tuberculosis and other conditions associated with malate synthase activity using these inhibitory compounds. Additionally, it includes the design of these compounds through in silico methods and provides three-dimensional X-ray crystal structures of the Mycobacterial malate synthase complexed with the inhibitory compounds.
Career Highlights
Ioerger is affiliated with The Texas A&M University System, where he continues to engage in research and innovation. His work has been instrumental in advancing the understanding of tuberculosis treatment and the development of new therapeutic strategies.
Collaborations
He has collaborated with notable colleagues such as Joel S Freundlich and James C Sacchettini, contributing to the advancement of research in his field.
Conclusion
Thomas R Ioerger's innovative work in developing inhibitors for Mycobacterial malate synthase represents a significant step forward in tuberculosis treatment. His contributions to biotechnology and collaboration with esteemed colleagues highlight his commitment to addressing critical health challenges.