Thomas Miller

Title: Thomas Miller: Innovator in Electrochemical Detection

Introduction

Thomas Miller is a notable inventor based in Bethesda, MD (US). He has made significant contributions to the field of electrochemical detection, particularly through his innovative approaches to the derivatization of amines.

Latest Patents

Miller holds a patent for the "Derivatization of amines for electrochemical detection." This patent describes a method where primary and secondary amines in biological fluids are selectively derivatized by reacting with esters of N-hydroxysuccinimide or N-hydroxysulfosuccinimide to form N-acylated derivatives. These derivatives can then be extracted into a polar organic phase for further analysis. Notably, non-electroactive amines can be made suitable for coulometric analysis by selecting the appropriate ester to attach an electroactive group to the amine. For instance, histamine can be reacted with the Bolton-Hunter reagent to yield a suitable derivative in high yield.

Career Highlights

Miller's work is conducted under the auspices of the United States of America as Represented by the Department of Health. His innovative research has led to advancements in the detection of biological compounds, enhancing the capabilities of electrochemical analysis.

Collaborations

Miller has collaborated with esteemed colleagues, including Kenneth Alan Jacobson and Kenneth L. Kirk, contributing to the advancement of research in his field.

Conclusion

Thomas Miller's contributions to the field of electrochemical detection through his innovative patent demonstrate his commitment to advancing scientific research. His work continues to influence the methods used in biological analysis today.