Company Filing History:
Years Active: 2001
Title: Thomas M Mariano: Innovator in Interferon Gamma Research
Introduction
Thomas M Mariano is a notable inventor based in Somerset, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the area of interferon gamma and its receptor. His work has implications for understanding immune responses and developing therapeutic strategies.
Latest Patents
Thomas M Mariano holds a patent for an invention titled "Accessory factory function for interferon gamma and its receptor." This invention encompasses several key components: (a) a 540 kb YAC that encodes necessary species-specific factors, substituting for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens; (b) the construction of a plasmid to integrate a selective marker for antibiotic G418 resistance into YACs, facilitating the manipulation of human genomic DNA; (c) two fragmentation vectors, pSE1 and pSE2, developed for targeting YACs containing human genomic DNA; (d) a chromosomal fragmentation procedure to produce a deletion set of YACs from a parental YAC known to map to Chromosome 21q; and (e) the isolation of cDNA clones that encode the necessary species-specific factor.
Career Highlights
Thomas M Mariano is affiliated with the University of Medicine and Dentistry of New Jersey. His work at this institution has allowed him to explore innovative approaches in genetic research and biotechnology.
Collaborations
Throughout his career, Thomas has collaborated with esteemed colleagues such as Sidney Pestka and Serguei V Kotenko. These collaborations have further enriched his research and contributed to advancements in the field.
Conclusion
Thomas M Mariano's contributions to biotechnology, particularly in the realm of interferon gamma research, highlight his role as an influential inventor. His patent reflects a deep understanding of genetic manipulation and its potential applications in medicine.