Thomas J Dull

Title: Thomas J Dull: Innovator in Retroviral Technology

Introduction

Thomas J Dull is a prominent inventor based in San Francisco, CA (US). He has made significant contributions to the field of retroviral technology, holding a total of 7 patents. His work focuses on methods for producing high titer viruses and enhancing the efficiency of retroviral transduction in mammalian cells.

Latest Patents

Dull's latest patents include innovative methods for the production of high titer viruses. One of his notable inventions provides a novel retroviral packaging system. This system allows for the production of retroviral packaging plasmids and packagable vector transcripts from high expression plasmids after stable or transient transfection in mammalian cells. The result is the generation of high titers of recombinant retrovirus, which can effectively transduce mammalian target cells through cocultivation or supernatant infection. His methods are particularly useful for transducing primary human cells, including T cells and human hematopoietic stem cells, with foreign genes at high efficiencies.

Career Highlights

Throughout his career, Thomas J Dull has worked with notable companies such as Cell Genesys, Inc. and Genentech, Inc. His expertise in retroviral technology has positioned him as a key figure in the development of advanced methods for viral production and gene transduction.

Collaborations

Dull has collaborated with esteemed colleagues in the field, including Mitchell H Finer and Krisztina M Zsebo. These collaborations have furthered the advancements in retroviral research and applications.

Conclusion

Thomas J Dull's innovative work in retroviral technology has significantly impacted the field of gene therapy and viral production. His contributions continue to pave the way for advancements in medical research and treatment methodologies.