Thomas H Frame

Title: Innovations by Thomas H Frame in Bloodgroup Antigen Detection

Introduction

Thomas H Frame is a notable inventor based in Spring, TX (US), recognized for his contributions to the field of bloodgroup antigen detection. He holds 2 patents that showcase his innovative methods and apparatuses designed to enhance the accuracy and efficiency of blood testing.

Latest Patents

His latest patents include a method and apparatus useful for detecting bloodgroup antigens and antibodies. The first method involves a direct assay where a sample of erythrocytes is added to a reaction tube containing two layers of immunoreactive particles. The first layer, preferably Sepharose, has Protein G coupled to its surface, while the second layer, preferably Sephacryl S-200, has Protein A coupled to it in a buffer solution. Antibodies specific for the bloodgroup antigens are coupled to the Protein G. The reaction tube is then centrifuged to separate erythrocytes that do not attach to the antibodies. The indirect assay follows a similar principle, where samples of erythrocytes, blood serum, or blood plasma are mixed with known antibody or antigen reagents, incubated, and then centrifuged to achieve the desired results.

Career Highlights

Thomas H Frame is associated with Gamma Biologicals, Inc., where he applies his expertise in developing innovative solutions for blood testing. His work has significantly contributed to advancements in medical diagnostics.

Collaborations

He has collaborated with notable coworkers, including David E Hatcher and John J Moulds, who have also contributed to the field of bloodgroup antigen detection.

Conclusion

Thomas H Frame's innovative methods for detecting bloodgroup antigens and antibodies represent significant advancements in medical diagnostics. His contributions continue to impact the field positively, enhancing the accuracy of blood testing procedures.