Thomas E Januario

Title: Thomas E. Januario: Innovator in Cancer Treatment

Introduction

Thomas E. Januario is a prominent inventor based in San Francisco, CA. He has made significant contributions to the field of cancer treatment through his innovative methods and research. With a total of 3 patents, his work focuses on advancing the understanding and treatment of cancer.

Latest Patents

One of his latest patents is titled "Methods for diagnosing and treating cancer." This invention provides methods of treating cancer based on the methylation status of the ERBB2 gene. It includes a method of administering an EGFR inhibitor therapy based on this methylation status. Another notable patent is "Mutant smoothened and methods of using the same." This invention addresses the emergence of mutations in tyrosine kinases that lead to acquired drug resistance in cancer patients. It describes a mutation in the serpentine receptor, Smoothened (SMO), which results in resistance to a Hedgehog (Hh) pathway inhibitor in medulloblastoma. The invention also provides screening methods to detect SMO mutations and methods to screen for drugs that specifically modulate mutant SMO exhibiting drug resistance.

Career Highlights

Throughout his career, Thomas E. Januario has worked with leading companies in the biotechnology sector, including Genentech, Inc. and Curis, Inc. His experience in these organizations has allowed him to collaborate with some of the brightest minds in the field.

Collaborations

Some of his notable coworkers include Frederic J. De Sauvage and Robert L. Yauch. Their collaborative efforts have contributed to the advancement of cancer research and treatment methodologies.

Conclusion

Thomas E. Januario's innovative work in cancer treatment exemplifies the impact of dedicated inventors in the medical field. His patents and collaborations continue to pave the way for new therapeutic approaches in oncology.