Location History:
- Kalamazoo, MI (US) (1978)
- Kalamazoo Township, Kalamazoo County, MI (US) (1982 - 1985)
- Eugene, OR (US) (1987)
Company Filing History:
Years Active: 1978-1987
Title: Thomas A. Hylton: Innovator in Pharmaceutical Chemistry
Introduction
Thomas A. Hylton is a notable inventor based in Kalamazoo, MI (US). He has made significant contributions to the field of pharmaceutical chemistry, holding a total of 5 patents. His work focuses on innovative processes that enhance the production and efficacy of pharmaceutical compounds.
Latest Patents
Hylton's latest patents include the development of a non-hygroscopic adinazolam methanesulfonate salt. This crystalline compound is preparable from a mixture of xylene or a C1 to C2 alkanol and C4 to C6 alkyl acetate. This innovation aids the processability of adinazolam methanesulfonate in pharmaceutical production plants. Additionally, he has described novel processes for the preparation of hydratropic acids. One such process involves carboxylating specific Grignard compounds, which are products of a catalyzed reaction between arylmagnesium bromides and ethylene. Furthermore, Hylton has disclosed an improved method for making coupled aryl compounds, which serve as intermediates for pharmaceutical applications. His work also includes an improved bromination process that yields high amounts of 4-bromo-2-fluoroaniline, which is subsequently coupled with benzene to produce the desired arylpropionic acid.
Career Highlights
Hylton is associated with The Upjohn Company, where he has contributed to various innovative projects. His expertise in pharmaceutical chemistry has positioned him as a key figure in the development of new compounds and processes that enhance drug production.
Collaborations
Throughout his career, Hylton has collaborated with notable colleagues such as Francis L. Shenton and Jerry A. Walker. These collaborations have further enriched his work and contributed to advancements in the field.
Conclusion
Thomas A. Hylton's contributions to pharmaceutical chemistry through his patents and innovative processes have made a significant impact on the industry. His work continues to influence the development of effective pharmaceutical compounds.