Thibaut Crepin

Title: The Innovative Work of Thibaut Crepin in Virology

Introduction

Thibaut Crepin, an accomplished inventor based in Grenoble, France, has carved out a significant niche in the field of virology. His groundbreaking research, particularly in endonuclease activity, is geared toward understanding and combating viral infections, specifically those caused by the Orthomyxoviridae family.

Latest Patents

Thibaut Crepin holds a notable patent titled "Polypeptide fragments comprising endonuclease activity and their use." This invention focuses on polypeptide fragments that include an amino-terminal fragment of the PA subunit from a viral RNA-dependent RNA polymerase, alongside its variants with endonuclease activity. The patent emphasizes the utilization of these polypeptides in developing methods for structure determination via X-ray crystallography and computational methods to design compounds that can modulate, preferably inhibit, the endonucleolytically active site of the polypeptide fragment. Moreover, the invention discusses high-throughput methods for identifying compounds that bind to these PA polypeptide fragments to inhibit their endonucleolytic activity, ultimately contributing to therapeutic applications against viral diseases stemming from Orthomyxoviridae viruses.

Career Highlights

Throughout his career, Thibaut Crepin has made significant strides in the realm of molecular biology and virology. He has worked with prestigious research institutions, including the European Molecular Biology Laboratory (EMBL) and the Centre National de la Recherche Scientifique, where he has contributed to advancing scientific knowledge and developing innovative solutions to combat viral infections.

Collaborations

Thibaut has had the opportunity to collaborate with esteemed colleagues, including Denis Bouvier and Rob Ruigrok. These collaborations have fostered an environment of innovation and have been instrumental in the advancement of his research endeavors.

Conclusion

Thibaut Crepin's contributions to the field of virology, marked by his innovative patent on polypeptide fragments and their applications, highlight his commitment to addressing public health challenges posed by viral infections. His collaborations and work at renowned research institutions underscore his role as a pivotal figure in the ongoing battle against viral diseases.