Company Filing History:
Years Active: 2000-2002
Title: The Innovations of Theodore Samuel Kalbfleisch
Introduction
Theodore Samuel Kalbfleisch is a notable inventor based in Branford, CT (US). He has made significant contributions to the field of protein-protein interactions, with a focus on methods for detecting and analyzing these interactions. His work has implications for understanding biological processes and developing potential therapeutic interventions.
Latest Patents
Kalbfleisch holds 2 patents that detail innovative methods for identifying and comparing protein-protein interactions. His latest patents describe techniques for detecting interactions among two populations of proteins, each with a complexity of at least 100. The methods involve fusing proteins to the DNA-binding domain or activation domain of a transcriptional activator. By mating two yeast strains carrying different fusion proteins, productive interactions can lead to the reconstitution of a transcriptional activator, activating a reporter gene. This analysis can be extended to multiple protein populations, allowing for the characterization of genes involved in specific interactions relevant to various biological contexts. Additionally, his patents outline methods for identifying inhibitors that can disrupt these interactions, which can be screened in a multiplexed format.
Career Highlights
Kalbfleisch has worked at Curagen Corporation, where he has applied his expertise in protein interactions to advance research and development. His innovative approaches have contributed to the understanding of complex biological systems and the identification of potential therapeutic targets.
Collaborations
He has collaborated with notable colleagues, including Krishnan Nandabalan and Jonathan Marc Rothberg, to further enhance the impact of his research in the field of protein interactions.
Conclusion
Theodore Samuel Kalbfleisch's work exemplifies the intersection of innovation and biological research, providing valuable insights into protein interactions and their implications for health and disease. His contributions continue to influence the scientific community and pave the way for future advancements.
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