Company Filing History:
Years Active: 1994-2002
Title: The Innovations of Theodore S. Widlanski
Introduction
Theodore S. Widlanski is a notable inventor based in Bloomington, Indiana, with a significant contribution to the field of biochemistry. He holds five patents that showcase his innovative approaches to nucleoside triphosphates and their applications in polymerization processes. His work has implications for both research and practical applications in molecular biology.
Latest Patents
One of Widlanski's latest patents involves the development of γ-phosphoester nucleoside triphosphates. This invention provides methods and compositions for polymerizing specific nucleotides using a polymerase. The method includes forming a mixture of a polymerase and a nucleoside triphosphate (NTP) that comprises α, β, and γ phosphates along with a γ-phosphate phosphoester-linked functional group. The polymerase catalyzes the cleavage of the NTP, liberating a pyrophosphate that incorporates the nucleoside monophosphate into a nascent polynucleotide. Additionally, he has developed analogues of RNA and DNA compounds that feature a neutral, stereoregular linking group, replacing the phosphoryl with a sulfonyl group. His patents also describe methods for preparing these precursors and analogues.
Career Highlights
Widlanski has had a distinguished career, working with reputable institutions such as the Advanced Research & Technology Institute and Indiana University. His research has significantly advanced the understanding of nucleic acid chemistry and polymerization techniques.
Collaborations
Throughout his career, Widlanski has collaborated with notable colleagues, including C Cheng Kao and William Vassiliou. These partnerships have contributed to the success of his research and innovations.
Conclusion
Theodore S. Widlanski's contributions to the field of biochemistry through his patents and research collaborations highlight his role as a significant inventor. His work continues to influence advancements in molecular biology and related fields.
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