Thangamani Muthukumar

Title: Innovations by Thangamani Muthukumar

Introduction

Thangamani Muthukumar is an accomplished inventor based in New York, NY (US). He has made significant contributions to the field of medical technology, particularly in organ transplantation and kidney diagnostics. With a total of 3 patents, his work has the potential to greatly improve patient outcomes.

Latest Patents

One of his latest patents is a method to match organ donors to recipients for transplantation. This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. It utilizes genomic data available before transplantation and predicts kidney graft function for more than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with time after transplantation. A low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.

Another notable patent is a non-invasive method of diagnosing renal fibrosis. This method involves measuring mRNAs in urinary cells, offering a noninvasive means of diagnosing fibrosis in kidneys. The process includes measuring quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA in a test sample of cells obtained from urine. By determining whether the vimentin mRNA quantity is higher, the NKCC2 mRNA quantity is lower, or the E-cadherin mRNA is higher than in healthy urinary cells, the method can detect fibrotic kidney samples. Additionally, the quantities of these mRNAs can be normalized against the quantity of housekeeping gene RNA.

Career Highlights

Thangamani Muthukumar is affiliated with Cornell University, where he continues to advance research in his field. His innovative approaches have garnered attention and recognition within the medical community.

Collaborations

He has collaborated with notable colleagues such as Manikkam Suthanthiran and Ruchuang Ding, contributing to the advancement of medical research and technology.

Conclusion

Thangamani Muthukumar's work exemplifies the impact of innovation in the medical field, particularly in organ transplantation and kidney health. His patents reflect a commitment to improving patient care through scientific advancements.