Terry D Lee

Title: Innovations of Terry D Lee in Nano-Liquid Chromatography

Introduction

Terry D Lee is a notable inventor based in San Dimas, California, recognized for his contributions to the field of nano-liquid chromatography. With a total of six patents to his name, Lee has made significant advancements in the integration of microfabricated systems for analytical chemistry.

Latest Patents

One of Lee's latest patents is the IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it. This invention relates to packed-column nano-liquid chromatography (nano-LC) systems that are integrated on-chip, along with methods for producing and utilizing these systems. The microfabricated chip includes essential components such as a column, filters, an injector, and a detector, all fabricated using processes compatible with those conventionally used for integrated circuits. The column can be packed with various supports for different stationary phases, enabling the performance of multiple forms of nano-LC, including reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector is designed to inject nanoliter or picoliter-volume sample plugs at the column inlet. Additionally, an electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique enhances the pressure rating of the microfluidic system, allowing it to withstand the high pressures typically used in high-performance liquid chromatography (HPLC). The successful demonstration of on-chip sample injection, separation, and detection of mixtures of anions in water using ion-exchange nano-LC showcases the practical applications of this innovative technology.

Career Highlights

Throughout his career, Terry D Lee has worked with prestigious institutions such as the California Institute of Technology and City of Hope. His work has significantly impacted the field of analytical chemistry, particularly in the development of advanced chromatography systems.

Collaborations

Lee has collaborated with notable professionals in his field, including Yu-Chong Tai and Amish Desai. These collaborations have contributed to the advancement of technologies in nano-liquid chromatography.

Conclusion

Terry D Lee's innovative work in nano-liquid chromatography has paved the way for new analytical techniques and applications. His contributions continue to influence the field and inspire future advancements in microfabricated systems.