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Title: Terace M Fletcher: Innovator in Telomerase Modulation
Introduction
Terace M Fletcher is a notable inventor based in San Antonio, TX (US). He has made significant contributions to the field of cancer research, particularly in the modulation and inhibition of telomerase. With a total of 4 patents, his work has the potential to impact cancer treatment significantly.
Latest Patents
Fletcher's latest patents focus on methods for modulation and inhibition of telomerase. His research indicates that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells exhibit a processive telomerase activity. He discovered that nucleotide analogs, such as 7-deaza-2'-deoxyquanosine-5'-triphosphate (7-deaza-dGTP), serve as substrates for processive telomerase and can be incorporated into telomeric sequences. This incorporation affects the processivity of telomerase, converting it from a processive to a non-processive state. Furthermore, these nucleotide analogs inhibit the formation of G-quartets by telomeric sequences. Other methods he explored include partially cleaving the telomerase RNA to convert cancer processive telomerase to the more benign non-processive form. The nucleoside analogs exhibit various activities, including mediating allosteric-like inhibition of telomerase, premature termination and shortening of telomeric DNA, destabilization of telomeric structure and function, and ultimately leading to cell death. His understanding of telomerase modulation mechanisms has facilitated the design of new telomerase inhibitors and modulators, which have applications in cancer treatment.
Career Highlights
Fletcher has worked with prominent institutions, including the University of Texas System and the CTRC Research Foundation. His research has garnered attention for its innovative approach to addressing cancer at the molecular level.
Collaborations
Some of his notable coworkers include Shih-Fong Chen and Ira Maine, who have contributed to his research endeavors.
Conclusion
Terace M Fletcher's work in telomerase modulation represents a significant advancement in cancer research. His innovative methods and discoveries hold promise for developing effective cancer treatments.