Teng-Yi Huang

Title: The Innovative Contributions of Teng-Yi Huang

Introduction

Teng-Yi Huang is a prominent inventor based in Taipei, Taiwan. He has made significant contributions to the field of glycoprotein engineering and thermal therapy through his innovative patents. With a total of 3 patents, Huang's work has the potential to impact various medical applications.

Latest Patents

Huang's latest patents include groundbreaking advancements in glycosynthase variants for glycoprotein engineering. These novel enzymes, specifically EndoSd-D232M and EndoSz-D234M, are designed for glycoprotein engineering and homogeneous antibody remodeling. They exhibit glycan conjugation and modification activity at the conserved N297 glycosylation site of the Fc region of antibodies. The glycosynthase activities of these variants have been successfully applied to multiple monoclonal antibodies (mAbs) targeting various receptors, such as Globo H, SSEA-4, and Herceptin. The remodeled homogeneous antibody, mAb-G2S2, demonstrated an increased relative activity ranging from 3 to 26 folds in the ADCC assay.

Another significant patent involves a method for detecting temperature and protein denaturation during thermal therapy. This method utilizes multiple MR pulse sequences to generate response signals that provide information about the degree of protein denaturation and the temperature of the tissue being treated. This innovative approach enhances the effectiveness of thermal therapy by allowing for real-time monitoring of tissue conditions.

Career Highlights

Huang has worked with notable organizations, including the National Health Research Institutes and Obi Pharma Inc. His experience in these institutions has contributed to his expertise in the field of biotechnology and medical research.

Collaborations

Huang has collaborated with esteemed colleagues such as Wen-Yih Isaac Tseng and Hsu-Hsia Peng. These partnerships have fostered a collaborative environment that encourages innovation and the advancement of scientific knowledge.

Conclusion

Teng-Yi Huang's contributions to glycoprotein engineering and thermal therapy exemplify the impact of innovative thinking in the medical field. His patents not only advance scientific understanding but also hold promise for improving therapeutic outcomes.