Tatjana Naranda

Title: Tatjana Naranda: Innovator in Receptor Modulation

Introduction

Tatjana Naranda is a prominent inventor based in Mountain View, CA (US). She has made significant contributions to the field of receptor modulation, holding 2 patents that showcase her innovative approach to biochemistry and pharmacology.

Latest Patents

Her latest patents include "Affinity small molecules for the EPO receptor" and "Receptor derived peptides as modulators of receptor activity." The first patent involves compounds that complex with the modulating domain of the erythropoietin receptor (EPO-R). These compounds are designed to determine the presence of EPO-R and assess the ability of other molecules to bind to the modulating domain in competitive assays. They also induce a signal by EPO-R into a cell when bound in a physiological environment. The compounds are characterized by a six-membered heterocyclic ring comprising at least one nitrogen atom, including substituted triazolopyrimidine, pyridazinone, pyridine, and piperidine.

The second patent focuses on oligopeptides that correspond to a receptor's extracellular domain. These oligopeptides enhance or replace the physiological response of ligand binding to the corresponding receptor. They are utilized in the diagnosis and therapy of diseases involving inadequate receptor response and in screening drug candidates that affect receptor surface expression. Additionally, a modified receptor molecule is described, where the sequence corresponding to the regulatory peptide is modified or deleted for drug screening purposes.

Career Highlights

Throughout her career, Tatjana has worked with various companies, including Reception, Inc. and Receptron, Inc. Her work has significantly impacted the understanding and application of receptor modulation in therapeutic contexts.

Collaborations

Tatjana has collaborated with notable professionals in her field, including her coworker Lennart Olsson. Their joint efforts have contributed to advancements in receptor research and development.

Conclusion

Tatjana Naranda's innovative work in receptor modulation exemplifies her dedication to advancing biochemistry and pharmacology. Her patents reflect her commitment to improving therapeutic approaches and understanding receptor dynamics.