Company Filing History:
2 out of 3,685 
1 out of 3,439 
1 out of 787 
Years Active: 2008-2010
Title: **Tatiana Dracheva: Pioneering the Molecular Understanding of Lung Cancer**
Introduction
Tatiana Dracheva is an innovative inventor based in Rockville, MD, with a significant focus on the molecular characteristics of non-small cell lung cancer (NSCLC). With two patents to her name, her work has greatly contributed to the understanding and differentiation of various lung cancer subtypes, showcasing her dedication to advancing cancer research.
Latest Patents
Dracheva's most recent patent revolves around the molecular characteristics of non-small cell lung cancer. In her research, she utilized hierarchical clustering to analyze gene expression profiles generated by serial analysis of gene expression (SAGE) from nine normal lung epithelial cells alongside NSCLC samples. This groundbreaking study revealed a clear separation between normal and tumor samples, as well as differences among histopathological subtypes.
Of particular note, Dracheva identified 3,921 most abundant transcript tags, with a significant focus on 115 highly differentially expressed transcript tags that offered insights into the biological and pathological traits of the examined tissues. Adenocarcinomas exhibited high-level expression of proteins related to small airway functions, whereas squamous cell carcinomas showed overexpression of genes involved in detoxification and antioxidation processes. Additionally, the study indicated potential compromises in the p53 pathway in adenocarcinomas, underscoring the complexity of lung cancer biology.
Career Highlights
Dracheva has played a vital role in reputable institutions, with associations that include The Johns Hopkins University and the United States Department of Health and Human Services. Through these affiliations, she has been able to translate her research findings into practical applications that can potentially transform lung cancer treatment methodologies.
Collaborations
Throughout her career, Tatiana has collaborated with notable scientists and researchers, including Mariana S. Nacht and David Sidransky. Such collaborations have not only enriched her research but have also fostered an environment of innovation and discovery, essential for tackling complex health challenges like lung cancer.
Conclusion
Tatiana Dracheva stands out as a profound inventor in the realm of cancer research, particularly concerning non-small cell lung cancer. With her impressive patent portfolio and the collaborations she has fostered, Dracheva has made a lasting impact on our understanding of molecular signatures associated with lung cancer. Her ongoing work promises to play a significant role in future cancer therapeutics and diagnostics, making her a key figure in the fight against cancer.