This inventor holds 2 USPTO granted patents. Top assignee: The University of Texas System. Active years: 2002-2003.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2002-2003
Title: Innovations in Cancer Research by Tapas Mukopadhyay
Introduction
Tapas Mukopadhyay is a notable inventor based in Houston, TX, who has made significant contributions to the field of cancer research. He holds 2 patents that focus on innovative methods for inhibiting cellular proliferation, particularly in lung cancer cells.
Latest Patents
His latest patents include groundbreaking work on the inhibition of cellular proliferation using ras antisense molecules. These patents disclose methods and compositions for the selective inhibition of gene expression through the application of antisense RNA technology. In one exemplary embodiment, a human lung cancer cell line (NCI-H460a) with a homozygous spontaneous K-ras mutation was transfected with a recombinant plasmid that synthesizes a genomic segment of K-ras in antisense orientation. This approach specifically inhibited the translation of the mutated K-ras mRNA, while the expression of H-ras and N-ras remained unchanged. A remarkable three-fold growth inhibition occurred in H460a cells when the expression of the mutated ras p21 protein was down-regulated by antisense RNA, and the cells remained viable. Furthermore, the growth of H460a tumors in nu/nu mice was substantially reduced by the expressed K-ras antisense RNA.
Career Highlights
Tapas Mukopadhyay is affiliated with The University of Texas System, where he continues to advance research in cancer therapies. His work has garnered attention for its potential applications in treating lung cancer, a disease that poses significant challenges in the medical field.
Collaborations
He has collaborated with esteemed colleagues such as Jack A Roth and Michael A Tainsky, contributing to a rich environment of innovation and research.
Conclusion
Tapas Mukopadhyay's contributions to cancer research through his innovative patents highlight the importance of advancements in medical technology. His work not only enhances our understanding of gene expression but also opens new avenues for effective cancer treatments.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile