Company Filing History:
Years Active: 2014-2016
Title: Innovations of Inventor Tao Chen
Introduction
Tao Chen is a notable inventor based in Rotterdam, Netherlands. He has made significant contributions to the field of biotechnology, particularly in the development of soluble heavy-chain only antibodies. With a total of two patents to his name, his work is recognized for its potential therapeutic applications.
Latest Patents
Tao Chen's latest patents focus on high affinity, antigen-specific, soluble heavy chain-only antibodies. These inventions lack hallmark camelid-related amino acid substitutions and feature FR2 substitutions not found in traditional antibodies that comprise both heavy and light chains. His patents demonstrate increased net hydrophobicity within CDR1 and an increased number of charged amino acids present in CDR3. Additionally, they include one or more amino acid substitutions within the framework β-pleated sheet, leading to increased net hydrophobicity within FR1 and an increased number of charged amino acids present in FR3. The patents also provide VH domains with similar properties, gene segments for their production, methods for their production, transgenic animals, and therapeutic uses of the antibodies derived from the VH domains.
Career Highlights
Tao Chen is affiliated with the Erasmus University Medical Center, where he continues to advance his research and innovations. His work has garnered attention in the scientific community for its implications in therapeutic applications.
Collaborations
Some of his notable coworkers include Roger Kingdon Craig and Franklin Gerardus Grosveld, who contribute to the collaborative research environment at the Erasmus University Medical Center.
Conclusion
Tao Chen's innovative work in the field of soluble heavy-chain only antibodies showcases his commitment to advancing biotechnology. His patents reflect a significant step forward in therapeutic applications, highlighting the importance of his contributions to the scientific community.