Takkellapati S Rao

Title: Takkellapati S Rao: Innovator in Nucleoside Chemistry

Introduction

Takkellapati S Rao is a notable inventor based in The Woodlands, Texas. He has made significant contributions to the field of nucleoside chemistry, particularly through his innovative patent related to nucleosides and oligonucleosides.

Latest Patents

Takkellapati S Rao holds a patent for "Nucleosides and oligonucleosides with a phosphate-free internucleoside." This patent describes nucleoside derivatives that contain a nucleobase, a sugar, and an amino acid backbone. The synthesis of these nucleoside derivatives involves a series of steps, including the oxidation of the 3'-azido nucleoside derivative and coupling to a benzylated ester of an amino acid to yield the amide. The adenine, guanine, cytosine, and thymine nucleosides with an amino acid at the 5' terminus can be synthesized, allowing for the creation of oligonucleotides with an amino acid backbone.

Career Highlights

Throughout his career, Takkellapati S Rao has worked with various organizations, including Triplex Pharmaceutical Corporation and Baylor College of Medicine. His work has focused on advancing the understanding and application of nucleoside chemistry.

Collaborations

Takkellapati S Rao has collaborated with notable colleagues such as Rajender S Varma and Michael E Hogan. These collaborations have contributed to the advancement of research in his field.

Conclusion

Takkellapati S Rao's contributions to nucleoside chemistry through his innovative patent and collaborations highlight his role as a significant inventor in this specialized area. His work continues to influence the field and pave the way for future advancements.