Tak Hang William Chan

Title: Tak Hang William Chan: Innovator in Medical Research

Introduction

Tak Hang William Chan is a prominent inventor based in Hong Kong, CN. He has made significant contributions to the field of medical research, particularly in the development of novel therapeutic agents. With a total of 2 patents, his work focuses on innovative solutions for complex medical challenges.

Latest Patents

One of his latest patents involves the development of peptides for the specific inhibition of the Jag1-Notch1 pathway. Aberrant cross talk between Notch ligand (e.g., Jag1) and Notch receptor (e.g., Notch1) has been implicated in tumorigenesis in the colon. Inhibition of the Notch pathway is an attractive approach for treating diseases with upregulated Jag1, such as colorectal cancer (CRC). Traditional pan-notch inhibitors like gamma secretase inhibitors (GSIs) have been developed to inhibit Notch and its downstream events. However, severe gastrointestinal toxicity profiles impede the clinical development of GSIs. The present invention develops novel oligopeptides that specifically inhibit the Jag1-Notch1 pathway without interfering with DLL1-Notch1 or DLL4-Notch1, demonstrating a clear advantage over pan-notch inhibitors.

Another significant patent relates to the synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents. This invention encompasses a novel series of amine-containing flavonoids and compositions containing these compounds, as well as their synthesis and use. The invention also includes methods for the treatment and prevention of diseases, particularly parasitic infections such as Leishmaniasis, through the administration of these compounds.

Career Highlights

Tak Hang William Chan has worked with esteemed institutions, including The Hong Kong Polytechnic University and the Royal Institution for the Advancement of Learning/McGill University. His career reflects a commitment to advancing medical science through innovative research and development.

Collaborations

Throughout his career, Chan has collaborated with notable colleagues, including Larry Ming-Cheung Chow and Kin-Fai Chan. These partnerships have contributed to the success of his research endeavors and the advancement of his inventions.

Conclusion

Tak Hang William Chan is a distinguished inventor whose work in medical research has the potential to significantly impact the treatment of various diseases. His innovative patents reflect a deep understanding of complex biological pathways and a commitment to developing effective therapeutic solutions.