Company Filing History:
3 out of 417 
2 out of 27 
1 out of 2 Years Active: 2018-2021
Title: Tadaatsu Hanadate: Innovator in Pharmaceutical Chemistry
Introduction
Tadaatsu Hanadate is a notable inventor based in Tokyo, Japan. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of compounds aimed at treating nocturia. With a total of three patents to his name, Hanadate's work has the potential to impact the lives of many individuals suffering from this condition.
Latest Patents
One of Hanadate's latest patents involves a pyridine derivative designed to provide a pharmaceutical composition for treating nocturia. The invention addresses the need for a compound that can effectively inhibit the nocturnal activity of placental leucine aminopeptidase (P-LAP). By maintaining or increasing endogenous arginine vasopressin (AVP) levels, the compound enhances the antidiuretic effect, thereby reducing the frequency of nocturnal voids. The research has demonstrated that (2R)-3-amino-2-{[4-(substituted pyridine)-2-yl]methyl}-2-hydroxy-propanoic acid derivatives exhibit excellent P-LAP inhibitory activity. Evaluations in water-loaded rats have shown that these compounds can increase endogenous AVP levels and consequently reduce urine production, making them promising agents for treating nocturia.
Career Highlights
Throughout his career, Tadaatsu Hanadate has worked with prominent companies in the pharmaceutical industry. Notably, he has been associated with Astellas Pharma GmbH and Kotobuki Pharmaceutical Co. Ltd. His experience in these organizations has contributed to his expertise in developing innovative pharmaceutical solutions.
Collaborations
Hanadate has collaborated with esteemed colleagues, including Kenichi Kawaguchi and Akihiro Ishihata. These partnerships have fostered a collaborative environment that enhances the research and development of new pharmaceutical compounds.
Conclusion
Tadaatsu Hanadate is a distinguished inventor whose work in pharmaceutical chemistry is paving the way for innovative treatments for nocturia. His contributions, backed by his patents and collaborations, highlight the importance of research in improving patient care.