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Years Active: 2018-2024
Title: Sylvain Baize: Innovator in Viral Vaccine Development
Introduction
Sylvain Baize is a prominent inventor based in Lyons, France. He has made significant contributions to the field of virology, particularly in the development of vaccines against viral infections. With a total of 4 patents, Baize's work focuses on innovative approaches to combatting diseases caused by viruses.
Latest Patents
One of Baize's latest patents is related to a Lassa vaccine. This invention involves a recombinant measles virus that expresses Lassa virus polypeptides. It specifically concerns immunogenic Lassa virus particles that are expressed by a measles virus and/or virus-like particles (VLPs) containing proteins of the Lassa virus. These recombinant infectious particles are capable of replicating in a host after administration. The invention provides various means, including nucleic acid constructs, vectors, cells, and rescue systems, to produce these recombinant infectious particles. Additionally, it relates to the use of these particles in vaccine formulations for the treatment or prevention of Lassa virus infections.
Another significant patent involves an immunogenic composition comprising a recombinant attenuated Mopeia virus with a modified nucleoprotein that displays reduced exonuclease activity. This recombinant virus includes a genomic S segment that encodes a nucleoprotein with attenuated exonuclease activity and may also encode a non-Mopeia arenavirus glycoprotein. The use of this recombinant attenuated Mopeia virus aims to induce an immune response in subjects.
Career Highlights
Throughout his career, Sylvain Baize has worked with esteemed institutions such as Institut Pasteur and the Centre National de la Recherche Scientifique. His research has been pivotal in advancing the understanding and treatment of viral infections.
Collaborations
Baize has collaborated with notable colleagues, including Audrey Page and Xavier Carnec. Their combined expertise has contributed to the success of various research projects and innovations in the field.
Conclusion
Sylvain Baize's innovative work in vaccine development showcases his commitment to addressing viral infections through scientific research. His contributions continue to have a lasting impact on public health and the field of virology.