This inventor holds 1 USPTO granted patent. Top assignee: The United States of America as Represented by the Department of Health. Active years: 1999.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1999
Title: Syed V Kashmiri: Innovator in Immunoglobulin Technology
Introduction
Syed V Kashmiri is a notable inventor based in Gaithersburg, MD (US). He has made significant contributions to the field of immunology through his innovative patent. His work focuses on the production of a single-gene-encoded immunoglobulin, which has important implications for gene therapy and antibody development.
Latest Patents
Syed V Kashmiri holds a patent for the "Production of a single-gene-encoded immunoglobulin." This patent describes the construction of a single gene encoding a signal-chain immunoglobulin-like molecule. The single-gene approach circumvents inefficiencies inherent in delivering two genes into a mammalian cell and in the assembly of a functional immunoglobulin molecule. It also facilitates ex vivo transfection of cells for gene-therapy protocols. The single-chain protein comprises the heavy- and light-chain variable (V.sub.H and V.sub.L) domains of a monoclonal antibody covalently joined through a short linker peptide. The carboxyl end of a V domain is linked to the amino terminus of a human constant region, such as .gamma.1 Fc, through the hinge region. The single-chain protein assembles into a dimeric molecule of approximately 120 kDa and is secreted into the culture fluid. This innovative protein shows similar antigen binding affinity to that of chimeric or parental antibodies and mediates antibody-dependent cellular cytotoxicity (ADCC). This single-gene construct approach provides a way of generating an immunoglobulin-like molecule that retains the specificity, binding properties, and cytolytic activity of a parental monoclonal antibody, making it a useful therapeutic and diagnostic reagent against a range of antigens, such as human carcinomas.
Career Highlights
Syed V Kashmiri works for the United States of America as represented by the Department of Health. His work has been instrumental in advancing the field of immunology and has the potential to impact therapeutic strategies for various diseases.
Collaborations
Some of his notable coworkers include Jeffrey Schlom and Liming Shu. Their collaborative efforts contribute to the ongoing research and development in immunological therapies.
Conclusion
Syed V Kashmiri's innovative work in the field of immunoglobulin technology exemplifies the importance of single-gene constructs in
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile