This inventor holds 5 USPTO granted patents. Top assignees: Swey-Shen Alexchen, Other. Active years: 2009-2025.
Company Filing History:
1 out of 1 
3 out of 834,411 Years Active: 2009-2025
Title: Innovations by Swey-Shen Chen
Introduction
Swey-Shen Chen is a prominent inventor based in San Diego, CA. He has made significant contributions to the field of biotechnology, particularly in vaccine development. With a total of 5 patents, his work focuses on innovative solutions to combat viral infections and other diseases.
Latest Patents
One of his latest patents involves CoV-2 (CoV-n) antibody neutralizing and CTL vaccines using protein scaffolds and molecular evolution. This invention aims to conformationally constrain neutralizing B cell epitopes of CoV-2, utilizing protein scaffolds, including camelid VHH nanobody, to elicit neutralizing and blocking antibodies against viral infections. Additionally, CTL epitopes are designed from the open reading frame protein to provide cell-mediated viral protection. Furthermore, mRNA vaccines are prepared to elicit protective immunity and prevent cytokine storms.
Another significant patent is focused on universal non-classical MHC I vaccines. This invention enables the development of HLA-E-restricted antigenic peptides as universal vaccines to treat allergies, inflammation, autoimmune diseases, infectious diseases, and cancers. An algorithm was developed to predict HLA-E binding immunogenic or suppressor peptides of autologous and microbial origins. This innovative approach aims to load antigenic peptides onto non-polymorphic HLA-E, HLA-F, and HLA-G, thereby bypassing the highly polymorphic classical MHC I pathways.
Career Highlights
Throughout his career, Swey-Shen Chen has worked with various companies, including Swey-Shen Alexchen. His innovative work has positioned him as a key figure in the biotechnology sector, contributing to advancements in vaccine technology.
Collaborations
He has collaborated with notable individuals such as Yong-Min Yang and Theresa J Barankiewicz, further enhancing the impact of his research and inventions.
Conclusion
Swey-Shen Chen's contributions to vaccine development and biotechnology demonstrate his commitment to addressing critical health challenges. His innovative patents reflect a deep understanding of molecular biology and a dedication to improving public health outcomes.