Company Filing History:
Years Active: 2003
Title: Innovations in Gene Therapy by Susan Piraino
Introduction
Susan Piraino is a notable inventor based in Framingham, MA (US). She has made significant contributions to the field of gene therapy, particularly through her work on AAV vectors. Her innovative approaches have the potential to advance therapeutic techniques and improve patient outcomes.
Latest Patents
Susan Piraino holds a patent for "AAV vectors for gene therapy." This invention focuses on methods for generating high titer, contaminant-free, recombinant AAV vectors. It includes methods and genetic constructs for producing these vectors conveniently and in large quantities. Additionally, her patent outlines methods for delivering all essential viral proteins required in trans for high yields of recombinant AAV. The invention also introduces novel packaging cell lines that eliminate the need for cotransfection of vector and helper plasmids. Furthermore, it provides a reporter assay for determining AAV vector yield, along with recombinant AAV vectors in a pharmaceutically acceptable carrier. The methods described facilitate the delivery of a transgene of interest to a cell, compositions for delivering a DNA sequence encoding a desired polypeptide, and the creation of transgenic non-human mammals that express a human chromosome 19 AAV integration locus.
Career Highlights
Susan Piraino is currently associated with Genzyme Corporation, where she continues to work on innovative solutions in gene therapy. Her expertise and dedication to research have positioned her as a key figure in her field.
Collaborations
Throughout her career, Susan has collaborated with notable colleagues, including Samuel C. Wadsworth and Karen Vincent. These partnerships have contributed to the advancement of her research and the development of her patented technologies.
Conclusion
Susan Piraino's work in gene therapy exemplifies the impact of innovative thinking in the medical field. Her contributions through her patent on AAV vectors are paving the way for future advancements in therapeutic applications.