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Title: Susan Grass: Innovator in Immunology
Introduction
Susan Grass is a notable inventor based in St. Louis, MO (US). She has made significant contributions to the field of immunology, particularly through her innovative research and patents. With a total of 2 patents, her work focuses on the development of immunogenic proteins and peptides related to Haemophilus influenzae type b.
Latest Patents
Her latest patents include the outer membrane protein P1 and peptides of Haemophilus influenzae type B. The gene for the outer membrane protein P1 of Haemophilus influenzae b is expressed in E. coli. Methods for expression and demonstration of the immunogenicity of recombinant P1 and portions thereof are disclosed. An improved method for the purification of P1 is also detailed. The nucleotide sequence of the P1 gene and the derived amino acid sequence of the P1 protein are disclosed, along with the methods used to determine the same. Furthermore, methods for cloning and expressing the P1 gene, as well as the purification protocol for the P1 gene products, are described. Fourteen peptides corresponding to specific sequences of the mature P1 protein have been synthesized. The use of the P1 protein as immunogens for immunization against diseases caused by Haemophilus influenzae type b is highlighted, along with its potential as a carrier for conjugation with oligosaccharides to generate an efficacious vaccine. Additionally, P1 peptide-conjugates are disclosed as immunizing agents to elicit anti-Haemophilus influenzae type b antibodies.
Career Highlights
Throughout her career, Susan Grass has worked with esteemed organizations such as Connaught Laboratories Limited and Washington University. Her research has significantly advanced the understanding of immunogenic proteins and their applications in vaccine development.
Collaborations
Some of her notable coworkers include Robert S Munson, Jr and Pele Chong. Their collaborative efforts have contributed to the success of her research and innovations.
Conclusion
Susan Grass is a pioneering inventor whose work in immunology has the potential to impact vaccine development significantly. Her contributions through her patents and collaborations continue to advance the field and improve public health outcomes.