Company Filing History:
Years Active: 2014-2016
Title: Suranganie Dharmawardhane: Innovator in Cancer Research
Introduction
Suranganie Dharmawardhane is a prominent inventor based in San Juan, Puerto Rico. He has made significant contributions to the field of cancer research, particularly in the development of small-molecule inhibitors targeting Rac1 in metastatic cancer cells. With a total of 2 patents, his work is paving the way for innovative treatments in oncology.
Latest Patents
Dharmawardhane's latest patents include groundbreaking research on small-molecule inhibitors of Rac1 in metastatic cancer cells. One notable compound, EHop-016, demonstrates an IC50 of 1.1 µM, making it a 100-fold more efficient inhibitor of Rac activity compared to the established Rac/Rac-GEF inhibitor NSC23766. EHop-016 is specific for Rac1 and Rac3 at concentrations ≤5 mM, and at higher concentrations, it inhibits the closely related Cdc42. In studies involving MDA-MB-435 cells, EHop-016 effectively inhibits the association of the Rac-GEF Vav2 with a nucleotide-free Rac1(G15A), which has a high affinity for activated GEFs. Importantly, EHop-016 does not affect the association of the Rac-GEF Tiam-1 with Rac1(G15A) at similar concentrations. Furthermore, EHop-016 inhibits Rac activity in MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation in both cell lines. The compound also decreases Rac-downstream effects of p21-activated kinase (PAK)1 activity and directed migration of metastatic cancer cells, while maintaining cell viability at low concentrations (<5 µM).
Career Highlights
Dharmawardhane is affiliated with the University of Puerto Rico, where he conducts his research and develops innovative solutions for cancer treatment. His work has garnered attention for its potential impact on therapeutic strategies for metastatic cancer.
Collaborations
Some of his notable coworkers include Eliud Hernandez and Cornelis P Vlaar, who contribute to the collaborative efforts in advancing cancer research.
Conclusion
Suranganie Dharmawardhane's innovative work in developing small-molecule inhibitors represents a significant advancement in cancer research. His contributions are essential in the ongoing fight against metastatic cancer, showcasing the importance of innovation in
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