Company Filing History:
Years Active: 2012
Title: Innovations of SungBae Kim in Bioluminescent Probes
Introduction
SungBae Kim is a notable inventor based in Ibaraki, Japan. He has made significant contributions to the field of bioluminescent probes, particularly in the development of innovative technologies for detecting specific ligands in living cells. His work is characterized by a unique approach that combines molecular biology and biochemistry.
Latest Patents
SungBae Kim holds a patent for a single molecule-format bioluminescent probe. The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell. This probe includes a ligand-binding molecule that changes conformation upon binding to the ligand. The ligand-binding molecule consists of a ligand-binding domain (LBD) of a nuclear receptor and an LBD-interacting domain that is a co-activator peptide of the nuclear receptor. Additionally, the probe features an N-terminal polypeptide and a C-terminal polypeptide of a click beetle luciferase, which flank each end of the ligand-binding molecule. The N-CBLuc and C-CBLuc self-complement to generate a luminescent signal only upon binding of the ligand to the ligand-binding molecule. This innovative design allows for precise detection of target ligands in biological systems.
Career Highlights
SungBae Kim is affiliated with the National Institute of Advanced Industrial Science and Technology, where he conducts research and development in advanced technologies. His work has garnered attention for its potential applications in various fields, including medical diagnostics and biological research.
Collaborations
SungBae Kim has collaborated with esteemed colleagues such as Yoshio Umezawa and Moritoshi Sato. These collaborations have further enhanced the impact of his research and innovations in the scientific community.
Conclusion
SungBae Kim's contributions to the field of bioluminescent probes exemplify the intersection of innovation and practical application in scientific research. His patented technology represents a significant advancement in the detection of target-specific ligands, showcasing the potential for future developments in this area.
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