Subhash R Patel

Title: Subhash R Patel: Innovator in Pharmaceutical Synthesis

Introduction

Subhash R Patel is a notable inventor based in Chicago, IL, with a significant contribution to the field of pharmaceutical synthesis. He holds six patents, showcasing his innovative approach to drug development and synthesis processes. His work has been instrumental in improving existing methodologies, particularly in the synthesis of complex pharmaceutical compounds.

Latest Patents

One of Patel's latest patents is titled "One pot synthesis of tetrazole derivatives of rapamycin." This invention presents a single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on a large scale. The method enhances currently available synthesis schemes, making them more efficient. In this process, dried rapamycin is dissolved in isopropylacetate (IPAc), and the solution is cooled before adding 2,6-Lutidine. Triflic anhydride is then slowly added at -30°C, followed by the removal of salts through filtration. The addition of tetrazole and diisopropylethylamine (DIEA) leads to further processing, including concentration and purification through silica gel columns. The final product undergoes multiple purification steps to ensure high quality, demonstrating Patel's commitment to excellence in pharmaceutical synthesis.

Career Highlights

Throughout his career, Subhash R Patel has worked with prominent companies such as Abbott Laboratories Corporation and Novo Nordisk A/S. His experience in these organizations has allowed him to collaborate with leading experts in the field and contribute to groundbreaking research and development.

Collaborations

Patel has collaborated with notable colleagues, including Michael S Allen and Ramiya H Premchandran. These partnerships have fostered an environment of innovation and creativity, leading to significant advancements in pharmaceutical synthesis.

Conclusion

Subhash R Patel's contributions to the field of pharmaceutical synthesis are noteworthy, particularly through his innovative patents and collaborations. His work continues to influence the industry, paving the way for more efficient drug development processes.