Company Filing History:
Years Active: 1985-1998
Title: The Innovative Contributions of Stuart E Builder
Introduction
Stuart E Builder is a prominent inventor based in Belmont, CA, known for his significant contributions to the field of biotechnology. With a total of 15 patents to his name, he has made remarkable advancements in the refolding of polypeptides, particularly in relation to recombinant insulin-like growth factor.
Latest Patents
One of his latest patents focuses on the refolding of polypeptides. This patent describes a composition that includes about 0.1 to 15 mg/mL of a polypeptide in a buffer with a pH of approximately 7-12. The buffer comprises about 5-40% (v/v) of an alcoholic or polar aprotic solvent, along with about 0.2 to 3M of an alkaline earth, alkali metal, or ammonium salt. Additionally, it contains about 0.1 to 9M of a chaotropic agent and about 0.01 to 15 µM of a copper or manganese salt. This innovative buffer is designed to effectively refold improperly folded polypeptides.
Career Highlights
Stuart E Builder has built a successful career at Genentech, Inc., where he has been instrumental in various research projects. His work has not only advanced scientific understanding but has also contributed to the development of therapeutic solutions in the biotechnology sector.
Collaborations
Throughout his career, Stuart has collaborated with notable colleagues, including David Reifsnyder and John R Ogez. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas.
Conclusion
Stuart E Builder's contributions to biotechnology, particularly in the area of polypeptide refolding, highlight his role as a leading inventor in the field. His work continues to influence advancements in therapeutic applications and showcases the importance of innovation in science.