Steven T Suhr

Title: Innovations and Contributions of Steven T. Suhr

Introduction

Steven T. Suhr is a notable inventor based in La Jolla, California. He has made significant contributions to the field of biological studies, particularly in the area of hormone receptor functionality. With a total of four patents to his name, Suhr's work has advanced our understanding of protein interactions and gene expression modulation.

Latest Patents

One of Suhr's latest patents is titled "Hormone receptor functional dimers and methods of their use." This invention provides chimeric proteins that consist of at least two functional protein units, each containing a dimerization domain from the steroid/thyroid hormone nuclear receptor superfamily. These chimeric proteins can fold under crystallization conditions to form functional entities. The invention also includes a novel flexible peptide linker designed to aid in the preparation of variant chimeric proteins. The DNA binding characteristics of these functional entities differ from those of wild-type complexes, allowing for various applications in gene expression modulation.

Another significant patent is "Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression." This invention highlights the utility of nuclear receptor proteins isolated from the silk moth, which have been found to be effective in regulating transgene expression in both silk moth and mammalian cells. The addition of activation domains enhances the transcriptional induction capabilities of these receptors, showcasing their potential in genetic research and biotechnology.

Career Highlights

Steven T. Suhr is affiliated with the Salk Institute for Biological Studies, where he conducts his research. His work has been instrumental in exploring the complexities of protein interactions and their implications for gene regulation. Suhr's innovative approaches have led to advancements in the understanding of hormone receptors and their applications in various biological contexts.

Collaborations

Suhr has collaborated with esteemed colleagues such as Fred Harrison Gage and Elad B. Gil. These collaborations have further enriched his research and contributed to the development of groundbreaking inventions in the field of biological studies.

Conclusion

Steven T. Suhr's contributions to the field of biological studies through his innovative patents and research at the Salk Institute for Biological Studies have significantly advanced our understanding of hormone receptors and gene expression. His work continues to inspire future research and innovation in the field.