Company Filing History:
Years Active: 2001-2005
Title: Steven R Head: Innovator in Nucleic Acid Sequencing
Introduction
Steven R Head is a notable inventor based in Manchester, MD (US), recognized for his contributions to the field of nucleic acid sequencing. With a total of 4 patents, he has made significant advancements that enhance the analysis of genetic material.
Latest Patents
Among his latest patents, the "De novo or 'universal' sequencing array" stands out. This invention describes a novel nucleic acid sequencing reagent that consists of a capture moiety, a spacer region, and a sequence-specific hybridizing region of 4-8 bases. The reagent can also include an attachment moiety and can be arranged into a nested array. This configuration allows for sequencing a given template without prior knowledge of the wild type or expected sequence, in conjunction with primer extension using a labeled chain-terminating nucleotide. Another significant patent is the "Polymerase signaling assay," which relates to nucleic acid sequence analysis. This invention provides methods for performing a polymerase signal assay (PSA) to analyze nucleotide sequences using solid-phase sequence arrays comprising a plurality of sequence reagents with primer sequences 4-6 bases in length. The methods generate a binary signal pattern that can identify nucleic acid sequences, mutations, and polymorphisms, including single nucleotide polymorphisms (SNPs), base deletions, and insertions.
Career Highlights
Steven has worked with prominent companies in the biotechnology sector, including Orchid Biosciences, Inc. and Beckman Coulter, Inc. His experience in these organizations has contributed to his expertise in nucleic acid sequencing technologies.
Collaborations
Throughout his career, Steven has collaborated with notable professionals, including Michael T Boyce-Jacino and Philip Goelet. These collaborations have further enriched his work and innovations in the field.
Conclusion
Steven R Head's contributions to nucleic acid sequencing through his patents and career experiences highlight his role as an influential inventor in biotechnology. His work continues to impact the field significantly.