Location History:
- Newtown, MA (US) (2001)
- Newton, MA (US) (1996 - 2006)
Company Filing History:
6 out of 2,893 
1 out of 832,843 Years Active: 1996-2006
Title: The Innovations of Steven M Reppert
Introduction
Steven M Reppert is a prominent inventor based in Newton, MA (US). He has made significant contributions to the field of circadian rhythm research, holding a total of 7 patents. His work focuses on the mechanisms of melatonin receptors and their applications in treating various disorders.
Latest Patents
One of Reppert's latest patents is titled "High-affinity melatonin receptor and uses thereof." This invention discloses cDNAs and DNAs encoding high-affinity melatonin 1a and 1b receptors. The recombinant polypeptides expressed from these cDNAs are utilized in methods for screening candidate compounds that act as agonists or antagonists to the effects of melatonin interaction with its receptors. Agonists are particularly useful in reentraining endogenous melatonin rhythms, which can help treat circadian rhythm disorders in humans and control reproductive cycles in seasonally breeding animals. Conversely, antagonists can be used therapeutically to manage the initiation or timing of puberty in humans. Additionally, the patent includes antibodies specific for high-affinity melatonin receptors and their therapeutic applications.
Another significant invention by Reppert involves methods for identifying compounds that modulate circadian rhythm. This invention is based on the discovery that CRY proteins and the PER2 protein play crucial roles in regulating mammalian circadian rhythms. The methods outlined in this patent provide a framework for modulating circadian rhythms and identifying compounds that can influence these biological processes.
Career Highlights
Throughout his career, Steven M Reppert has worked with notable organizations, including the General Hospital Corporation. His research has significantly advanced the understanding of circadian biology and its implications for health and disease.
Collaborations
Reppert has collaborated with esteemed colleagues such as Takashi Ebisawa and Valentin K Gribkoff. These partnerships have contributed to the depth and breadth of his research in the field.
Conclusion
Steven M Reppert's innovative work in circadian rhythm research and melatonin receptor biology has led to important advancements in therapeutic applications. His contributions continue to influence the scientific community and improve our understanding of biological rhythms.