Company Filing History:
Years Active: 2008-2024
Title: Innovations and Contributions of Inventor Steven Idell
Introduction
Steven Idell is a notable inventor based in Tyler, Texas, who has made significant contributions to the field of pulmonary medicine. With a total of 11 patents to his name, Idell's work focuses on innovative treatments for idiopathic pulmonary fibrosis (IPF), a serious lung condition.
Latest Patents
Idell's latest patents include groundbreaking research on the inhibition of pulmonary fibrosis using nutlin-3A and peptides. His findings indicate that in fibrotic lung fibroblasts, the basal levels of p53 protein and miR-34a are markedly suppressed. This suppression leads to reduced p53-mediated inhibition of uPA and uPAR, contributing to excessive fibroblast proliferation and extracellular matrix production, which are hallmarks of pulmonary fibrosis. By treating these cells with nutlin-3A or the peptide CSP-4, Idell has demonstrated a new approach to restoring p53 expression and mitigating the effects of IPF. Another significant patent involves the use of glycogen synthase kinase 3 (GSK-3β) inhibitors, particularly 9-ING-41, to inhibit fibrotic pulmonary remodeling in vivo. This therapeutic targeting provides a promising mode of therapy for human IPF.
Career Highlights
Throughout his career, Steven Idell has worked with esteemed organizations such as the University of Texas System and Actuate Therapeutics Inc. His research has been pivotal in advancing the understanding and treatment of pulmonary fibrosis, showcasing his dedication to improving patient outcomes.
Collaborations
Idell has collaborated with notable colleagues, including Sreerama Shetty and Torry A Tucker, further enhancing the impact of his research through teamwork and shared expertise.
Conclusion
Steven Idell's innovative work in the field of pulmonary medicine, particularly regarding idiopathic pulmonary fibrosis, highlights his significant contributions as an inventor. His patents and research continue to pave the way for new therapeutic approaches, ultimately benefiting patients suffering from this challenging condition.