The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
May. 16, 2019
Applicant:
Actuate Therapeutics Inc., Fort Worth, TX (US);
Inventors:
Torry A. Tucker, Tyler, TX (US);
Steven Idell, Tyler, TX (US);
Assignee:
ACTUATE THERAPEUTICS INC., Fort Worth, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/407 (2006.01); A61K 9/00 (2006.01); A61P 11/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/407 (2013.01); A61K 9/0073 (2013.01); A61P 11/00 (2018.01);
Abstract
Pharmaceutical compositions and methods are described which rely upon glycogen synthase kinase 3 (form β; GSK 3 β) inhibitors, most preferably 9-ING-41, to inhibit fibrotic pulmonary remodeling in vivo including proliferation and differentiation of myofibroblasts to fibrotic fibroblasts in several mouse models. Therapeutic targeting of GSK-3β with the clinically useful specific inhibitor, 9-ING-41, mitigates fibrotic pulmonary remodeling in vivo and provides a mode of therapy of human IPF by specific GSK-3β inhibition with 9-ING-41.