Company Filing History:
Years Active: 1989-2024
Title: The Innovations of Steven Henikoff
Introduction
Steven Henikoff is a prominent inventor based in Seattle, WA, known for his significant contributions to the field of genomics. With a total of four patents to his name, Henikoff has made strides in understanding chromatin dynamics and gene regulation. His work has implications for both basic research and therapeutic applications.
Latest Patents
Henikoff's latest patents focus on high-efficiency targeted in situ genome-wide profiling. This innovative method allows for the detection of the binding of chromatin-associated factors to specific sequences of chromatin DNA within cells. The process involves contacting a permeabilized cell or nucleus with a specific binding agent that recognizes the chromatin-associated factor of interest. This binding agent is linked to a nuclease that is either inactive or an activatable transposome. By activating the nuclease or transposase, the sequence of chromatin DNA bound to the factor can be excised, isolated, and sequenced, thereby providing insights into the binding dynamics of chromatin-associated factors.
Career Highlights
Throughout his career, Henikoff has worked at notable institutions, including the Fred Hutchinson Cancer Center and the Fred Hutchinson Cancer Research Center. His research has been pivotal in advancing our understanding of chromatin biology and its role in gene expression.
Collaborations
Henikoff has collaborated with esteemed colleagues such as Richard Evan Gelinas and Hatice Seda Kaya Okur. These collaborations have further enriched his research and contributed to the scientific community's understanding of chromatin dynamics.
Conclusion
Steven Henikoff's innovative work in genomics and chromatin biology has established him as a leading figure in his field. His patents and research continue to influence the landscape of genetic research and therapeutic development.
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